Imidazole → 3-Chloro-6-(1H-imidazol-1-yl)pyridazine

HRID 466550ノート

反応式

HRID 466550 の反応式
[NH:1]1[CH:5]=[CH:4][N:3]=[CH:2]1.[H-].[Na+].[Cl:8][C:9]1[N:10]=[N:11][C:12](Cl)=[CH:13][CH:14]=1>CN(C)C=O>[Cl:8][C:9]1[N:10]=[N:11][C:12]([N:1]2[CH:5]=[CH:4][N:3]=[CH:2]2)=[CH:13][CH:14]=1

参加物

5

反応物 3

HCID 795ImidazoleHCID 24758Sodium hydrideHCID 673313,6-Dichloropyridazine

生成物 1

HCID 27709033-Chloro-6-(1H-imidazol-1-yl)pyridazine

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒2 回

実験手順

A mixture of 47.6 parts of 1H-imidazole, 33.6 parts of sodium hydride dispersion 50% and 750 parts of N,N-dimethylformamide was stirred at room temperature for 15 minutes. The resulting solution was added to 106 parts of 3,6-dichloropyridazine in 750 parts of N,N-dimethylformamide and the whole was further stirred for 2 days at room temperature. The product was extracted with trichloromethane. The extract was dried, filtered and evaporated. The residue was crystalized from methanol. The product was filtered off, washed with petroleumether and dried, yielding 48.5 parts of 3-chloro-6-(1H-imidazol-1-yl)pyridazine; mp. 182.9° C. (compound 1).

後処理

  1. stirringthe whole was further stirred for 2 days at room temperature
  2. extractionThe product was extracted with trichloromethane
  3. customThe extract was dried
  4. filtrationfiltered
  5. customevaporated
  6. customThe residue was crystalized from methanol
  7. filtrationThe product was filtered off
  8. washwashed with petroleumether
  9. customdried

出典と根拠

ORDレコード
ord-dd034327fcca4d8393b7947d001d140c
出典データセット
uspto-grants-1992_10
特許番号
US05157035

反応ノート

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