Butyl bromide → 2,3-Dichloro-4-methoxy-N-n-butylaniline

HRID 466591

反応式

HRID 466591 の反応式
[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([O:10][CH3:11])[CH:6]=[CH:5][C:3]=1[NH2:4].[CH2:12](Br)[CH2:13][CH2:14][CH3:15].C(=O)([O-])O.[Na+]>COCCO>[Cl:1][C:2]1[C:8]([Cl:9])=[C:7]([O:10][CH3:11])[CH:6]=[CH:5][C:3]=1[NH:4][CH2:12][CH2:13][CH2:14][CH3:15]

参加物

5

反応物 3

HCID 8002Butyl bromideHCID 516892Sodium BicarbonateHCID 136906392,3-Dichloro-4-methoxyaniline

生成物 1

HCID 136884512,3-Dichloro-4-methoxy-N-n-butylaniline

試薬・触媒・溶媒 1

HCID 80192-Methoxyethanol溶媒

実験手順

A mixture of 2,3-dichloro-4-methoxyaniline (19.2 g), n-butylbromide (22.0 g), sodium hydrogen carbonate (40 g) and methylcellosolve (350 ml) is stirred at 95°-100° C. for about 48 hours. The cooled mixture is filtered, and the filtrate is evaporated in vacuo. The remaining material is washed with water and is thereafter recrystallized from ethanol to give the title compound with a melting point of 47°-49° C.

後処理

  1. filtrationThe cooled mixture is filtered
  2. customthe filtrate is evaporated in vacuo
  3. washThe remaining material is washed with water
  4. customis thereafter recrystallized from ethanol

出典と根拠

ORDレコード
ord-8fb866fbda2a421cb6d9f91b2097482b
出典データセット
uspto-grants-1992_10
特許番号
US05157039

関連ノート

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