Sodium hydride → HCID 178437449、化合物

HRID 466692

反応式

HRID 466692 の反応式
[CH2:1]([C:3]1[NH:4][C:5]2[C:6]([N:12]=1)=[N:7][CH:8]=[CH:9][C:10]=2[CH3:11])[CH3:2].[C:13]1([C:19]([C:45]2[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=2)([C:39]2[CH:44]=[CH:43][CH:42]=[CH:41][CH:40]=2)[N:20]2[C:24]([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[C:31]3[CH:36]=[CH:35][C:34]([CH2:37]Br)=[CH:33][CH:32]=3)=[N:23][N:22]=[N:21]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.[H-].[Na+]>>[CH2:1]([C:3]1[N:12]([CH2:37][C:34]2[CH:33]=[CH:32][C:31]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[C:24]3[N:20]([C:19]([C:45]4[CH:50]=[CH:49][CH:48]=[CH:47][CH:46]=4)([C:39]4[CH:40]=[CH:41][CH:42]=[CH:43][CH:44]=4)[C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[N:21]=[N:22][N:23]=3)=[CH:36][CH:35]=2)[C:6]2=[N:7][CH:8]=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2].[CH2:1]([C:3]1[N:12]([CH2:37][C:34]2[CH:35]=[CH:36][C:31]([C:26]3[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=3[C:24]3[NH:20][N:21]=[N:22][N:23]=3)=[CH:32][CH:33]=2)[C:6]2=[N:7][CH:8]=[CH:9][C:10]([CH3:11])=[C:5]2[N:4]=1)[CH3:2]

参加物

5

反応物 3

HCID 24758Sodium hydrideHCID 100534615-(4'-(Bromomethyl)(1,1'-biphenyl)-2-yl)-1-trityl-1H-tetraazoleHCID 186930362-ethyl-7-methyl-3H-Imidazo[4,5-b]pyridine

生成物 2

HCID 131717588HCID 131717588、化合物HCID 178437449HCID 178437449、化合物収率 154.5%

実験手順

2-Ethyl-7-methyl-3(2'-(N-triphenylmethyltetrazol-5-yl)biphen-4-yl)methyl-3H-imidazo[4,5-b]pyridine was prepared according to the procedure described in Part A of Example 7, from 2-ethyl-7-methylimidazo[4,5-b]pyridine (0.5 g, 3.11 mmol), N-triphenylmethyl-5-(4'-bromomethylbiphenyl-2-yl)tetrazole (1.82 g, 3.26 mmol) and NaH (3.12 mmol). The crude product (1.9 g, foam) was purified by flash chromatography on silica-gel using EtOAc-hexanees (1:1.5) to give the desired product as a white solid (0.95 g, 47.5%).

後処理

  1. customThe crude product (1.9 g, foam) was purified by flash chromatography on silica-gel

出典と根拠

ORDレコード
ord-3819adc1f2a8477ea0320344597f7f55
出典データセット
uspto-grants-1992_10
特許番号
US05157026

関連ノート

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