Chloromethyl pivalate → Ticlopidine Hydrochloride
反応式
[C:1](OC[Cl:9])(=O)C(C)(C)C.[Cl:10][C:11]1[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=1[CH2:13][NH:14][CH2:15][CH2:16][C:17]1[S:18][CH:19]=[CH:20][CH:21]=1>CS(C)=O>[ClH:9].[Cl:10][C:11]1[CH:25]=[CH:24][CH:23]=[CH:22][C:12]=1[CH2:13][N:14]1[CH2:15][CH2:16][C:17]2[S:18][CH:19]=[CH:20][C:21]=2[CH2:1]1参加物
4
実験手順
66.5 g (0.44 M) chloromethyl pivalate is reacted by heating, for 3 hours, with a solution of 103 g (0.4 M) N-(2-chloro-benzyl)-2-(2-thienyl)ethylamine in 300 ml dimethylsulfoxide, to give the title compound in a yield of 51%.
出典と根拠
- ORDレコード
- ord-e1e3cd2e741d47f5826cb8f92d901749
- 出典データセット
- uspto-grants-1979_11
- 特許番号
- US04174448
反応ノート
読み込み中…