Propargyl bromide → HCID 15065591、化合物

HRID 466754ノート

反応式

HRID 466754 の反応式
[CH2:1](Br)[C:2]#[CH:3].[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH2:10])[CH3:6].[CH2:14]1[CH2:18]OC[CH2:15]1>>[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][N:10]([CH2:18][C:14]#[CH:15])[CH2:1][C:2]#[CH:3])[CH3:6].[CH2:5]([O:7][CH:8]([O:11][CH2:12][CH3:13])[CH2:9][NH:10][CH2:1][C:2]#[CH:3])[CH3:6]

参加物

5

反応物 3

HCID 7842Propargyl bromideHCID 8028TetrahydrofuranHCID 695242,2-Diethoxyethylamine

生成物 2

HCID 15065591HCID 15065591、化合物HCID 15065592HCID 15065592、化合物

実験手順

Propargyl bromide (14.7 g of 80% solution in toluene, 0.1 mol) was added to a stirred solution of aminoacetaldehyde diethyl acetal (13.3 g, 0.1 mol) in THF (200 mL). After 2 h the THF was removed and the residual oil was partitioned between ether and sodium hydroxide solution. Evaporation of the ether gave an oil which was chromatographed on silica gel to give 4.7 g of 2,2-diethoxy-N,N-bis-(2-propynyl)ethylamine and 8.1 g of 2,2-diethoxy-N-(2-propynyl)ethylamine.

後処理

  1. customAfter 2 h the THF was removed
  2. customthe residual oil was partitioned between ether and sodium hydroxide solution
  3. customEvaporation of the ether
  4. customgave an oil which
  5. customwas chromatographed on silica gel

出典と根拠

ORDレコード
ord-0698c25eb20042a9b73206f28b9ad3e5
出典データセット
uspto-grants-1992_10
特許番号
US05157124

反応ノート

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