Tetrabutylammonium Fluoride → 1-Decyn-3-ol

HRID 466804ノート

反応式

HRID 466804 の反応式
C[Si](C)(C)[C:3]#[C:4][CH:5]([OH:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>O1CCCC1>[CH:3]#[C:4][CH:5]([OH:13])[CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH3:12]

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 109552841-Decyn-3-ol, 1-(trimethylsilyl)-

生成物 1

HCID 109207291-Decyn-3-ol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Dissolve 1-trimethylsilyl-1-decyn-3-ol (2.07 g, 9.13 mmol) in tetrahydrofuran (11 mL) and place under an argon atmosphere. Add, by dropwise addition, tetra-n-butylammonium fluoride (11 mL of a 1M solution in tetrahydrofuran, 11 mmol). Stir for 1 hour at room temperature and partition between methylene chloride and water. Separate the organic phase, wash with saturated aqueous sodium chloride, dry (MgSO4), filter and evaporate the solvent in vacuo to give the title compound.

後処理

  1. custompartition between methylene chloride and water
  2. customSeparate the organic phase
  3. washwash with saturated aqueous sodium chloride
  4. dry with materialdry (MgSO4)
  5. filtrationfilter
  6. customevaporate the solvent in vacuo

出典と根拠

ORDレコード
ord-d93a649a9ef541aab87e984dfaebfa16
出典データセット
uspto-grants-1992_10
特許番号
US05157167

反応ノート

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