p-Toluenesulfonic acid → 1-(2-Hydroxy-3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)cyclopropane

HRID 466940ノート

反応式

HRID 466940 の反応式
COC[O:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=1[C:11]1([C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[C:16]([O:22][CH3:23])[C:15]=2[O:24]COC)[CH2:13][CH2:12]1.C1(C)C=CC(S(O)(=O)=O)=CC=1>CO>[OH:24][C:15]1[C:16]([O:22][CH3:23])=[C:17]([O:20][CH3:21])[CH:18]=[CH:19][C:14]=1[C:11]1([C:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=2[OH:4])[CH2:12][CH2:13]1

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 198126851-(2-Methoxymethoxyphenyl)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)cyclopropane

生成物 1

HCID 198126861-(2-Hydroxy-3,4-dimethoxyphenyl)-1-(2-hydroxyphenyl)cyclopropane収率 99.1%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 1.16 g (3.1 mmol) of 1-(2-methoxymethoxyphenyl)-1-(3,4-dimethoxy-2-methoxymethoxyphenyl)cyclopropane and 80 mg (0.47 mmol) of p-toluenesulfonic acid in 26 ml of methanol was heated at reflux with stirring for 2 hours under an argon atmosphere. The mixture was concentrated to half by evaporation under reduced pressure and 40 ml of ether was added. The resulting solution was extracted with 30 ml of 5 percent aqueous sodium bicarbonate then 30 ml of water, dried over magnesium sulfate, and concentrated by evaporation under reduced pressure to obtain 880 mg of the title compound as a foamy oil. The proton NMR spectrum was consistent with the assigned structure.

後処理

  1. temperatureat reflux
  2. concentrationThe mixture was concentrated to half by evaporation under reduced pressure and 40 ml of ether
  3. additionwas added
  4. extractionThe resulting solution was extracted with 30 ml of 5 percent aqueous sodium bicarbonate
  5. dry with material30 ml of water, dried over magnesium sulfate
  6. concentrationconcentrated by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-953cdb990814472794f71224c8a3d248
出典データセット
uspto-grants-1992_10
特許番号
US05158597

反応ノート

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