Methanesulfonyl chloride → N-(2-Methylquinolin-6-yl)methanesulfonamide

HRID 467103

反応式

HRID 467103 の反応式
[CH3:1][S:2](Cl)(=[O:4])=[O:3].[NH2:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[CH:11]=[CH:10]2>N1C=CC=CC=1>[CH3:1][S:2]([NH:6][C:7]1[CH:8]=[C:9]2[C:14](=[CH:15][CH:16]=1)[N:13]=[C:12]([CH3:17])[CH:11]=[CH:10]2)(=[O:4])=[O:3]

参加物

4

反応物 2

HCID 31297Methanesulfonyl chlorideHCID 1031482-Methylquinolin-6-amine

生成物 1

HCID 19813426N-(2-Methylquinolin-6-yl)methanesulfonamide

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

Methanesulphonyl chloride (6.2 ml) was added dropwise to a stirred solution of 6-amino-2-methylquinoline (12.5 g) in pyridine (100 ml) cooled to 5°. Stirring was continued for 17 hours at room temperature. The pyridine was then removed by evaporation in vacuo, the residue diluted with aqueous sodium bicarbonate, and extracted three times with methylene chloride. The combined organic extracts were combined, dried (MgSO4) and evaporated in vacuo to give the title compound, yield 13.0 g, m.p. 151°-153°.

後処理

  1. temperaturecooled to 5°
  2. customThe pyridine was then removed by evaporation in vacuo
  3. additionthe residue diluted with aqueous sodium bicarbonate
  4. extractionextracted three times with methylene chloride
  5. dry with materialdried (MgSO4)
  6. customevaporated in vacuo

出典と根拠

ORDレコード
ord-907df6cfe4be470890ec45e3296d630e
出典データセット
uspto-grants-1992_10
特許番号
US05158964

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