2-Fluorobenzoyl chloride → 2-(2-fluorobenzoyl)-N-methyl-1-hydrazinecarbothioamide
反応式
[CH3:1][NH:2][C:3](=[S:6])[NH:4][NH2:5].[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10](Cl)=[O:11].Cl.N1C=CC=CC=1>N1C=CC=CC=1>[F:7][C:8]1[CH:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([NH:5][NH:4][C:3]([NH:2][CH3:1])=[S:6])=[O:11]参加物
5
実験手順
To a stirred room temperature solution of 4-methylthiosemicarbazide (10.5 g, 1.00×10-1 mole) and pyridine (250 ml), 2-fluorobenzoyl chloride (11.9 ml, 1.00×10-1 mole) was added dropwise. After stirring overnight at room temperature the excess pyridine was evaporated at reduced pressure first on a rotary evaporator and then at high vacuum. This afforded a mixture of the desired product and pyridine hydrochloride which is used without further purification in the subsequent cyclization step.
後処理
- customwas evaporated at reduced pressure first on a rotary evaporator
- customThis afforded
出典と根拠
- ORDレコード
- ord-0e7f4bf8cf004d8d8755845dff39305d
- 出典データセット
- uspto-grants-1992_10
- 特許番号
- US05158968
反応ノート
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