Ethanol → 2-Amino-9-hydroxy-6-methoxypurine

HRID 467224ノート

反応式

HRID 467224 の反応式
[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[O:11]CC2C=CC=CC=2)=[C:4]([O:19][CH3:20])[N:3]=1.C(O)C>[Pd].O1CCOCC1>[NH2:1][C:2]1[N:10]=[C:9]2[C:5]([N:6]=[CH:7][N:8]2[OH:11])=[C:4]([O:19][CH3:20])[N:3]=1

参加物

5

反応物 2

HCID 702EthanolHCID 145239622-Amino-9-benzyloxy-6-methoxypurine

生成物 1

HCID 145239632-Amino-9-hydroxy-6-methoxypurine

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 312751,4-Dioxane溶媒

実験手順

A mixture of 2-amino-9-benzyloxy-6-methoxypurine (300mg, 1.11mmol), 10% palladium-on-charcoal (100mg), ethanol (10ml) and dioxan (5ml) was stirred under an atmosphere of hydrogen for 45 minutes. The catalyst was then removed and the filtrate evaporated to a white solid 2-amino-9-hydroxy-6-methoxypurine (190mg, 95%). IR: υmax (KBr) 3312, 1643, 1591, 1394cm-1 ; 1H NMR: δH [(CD3)2SO] 3.95 (3H, s, CH3), 6.45 (2H, br.s, D2O exchangeable, NH2), 7.93 (1H, s, H-8), 11.75 (1H, br.s, OH). Found: m/e 181.0594. C6H7N5O2 requires: m/e 181.0596.

後処理

  1. customThe catalyst was then removed
  2. customthe filtrate evaporated to a white solid 2-amino-9-hydroxy-6-methoxypurine (190mg, 95%)

出典と根拠

ORDレコード
ord-02da322ae3d04aeda52a6c3084db57ff
出典データセット
uspto-grants-1992_10
特許番号
US05159076

反応ノート

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