Acetic Acid → HCID 178447262、化合物

HRID 467236ノート

反応式

HRID 467236 の反応式
[C:1]([C:5]([NH:7][C:8]1[N:9]=[C:10]([OH:27])[C:11]2[CH2:17][CH:16]([CH2:18][O:19][Si](C(C)(C)C)(C)C)[CH2:15][NH:14][C:12]=2[N:13]=1)=[O:6])([CH3:4])([CH3:3])[CH3:2].C(O)(=O)C>C1COCC1.O>[C:1]([C:5]([NH:7][C:8]1[N:9]=[C:10]([OH:27])[C:11]2[CH2:17][CH:16]([CH2:18][OH:19])[CH2:15][NH:14][C:12]=2[N:13]=1)=[O:6])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 2

HCID 176Acetic AcidHCID 178447263HCID 178447263、化合物

生成物 1

HCID 178447262HCID 178447262、化合物収率 87.3%

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 8028Tetrahydrofuran溶媒

反応条件

温度
22 °C

実験手順

To a mixture of 5.0 g of 2-t-butylcarbonylamino-4-hydroxy-6-[t-butyl(dimethyl)silyloxymethyl]-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine in 50 ml of THF and 50 ml of water were added 150 ml of glacial acetic acid. The mixture was stirred 18 hours at 22° C. and then evaporated to a viscous oil. Water was added and the resulting white precipitate collected by filtration to give 3.1 g of the title compound: mp 236°-238° C.; Anal. Calcd for C19H34N4O3Si: C, 55.70; H, 7.19; N, 19.99. Found: C, 55.96; H, 7.25; N, 19.69.

後処理

  1. customevaporated to a viscous oil
  2. additionWater was added
  3. filtrationthe resulting white precipitate collected by filtration

出典と根拠

ORDレコード
ord-2e1f329321a841b89dc3aac96e68d409
出典データセット
uspto-grants-1992_10
特許番号
US05159079

反応ノート

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