Hydrochloric Acid → 2-Cyclohexylacetaldehyde

HRID 467271ノート

反応式

HRID 467271 の反応式
C[O:2][CH:3](OC)[CH2:4][CH:5]1[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1.Cl>O1CCCC1.C(OCC)C>[CH:5]1([CH2:4][CH:3]=[O:2])[CH2:10][CH2:9][CH2:8][CH2:7][CH2:6]1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 11052116Cyclohexylacetaldehyde dimethyl acetal

生成物 1

HCID 3166272-Cyclohexylacetaldehyde収率 131.7%

試薬・触媒・溶媒 2

HCID 3283Diethyl Ether溶媒HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of 60 gm (349 mMol) cyclohexylacetaldehyde dimethyl acetal in tetrahydrofuran (50 ml) and diethyl ether (100 ml) was added 1N hydrochloric acid (200 ml) and the resulting mixture was stirred for 2.5 hours at room temperature. The reaction mixture was then partitioned between diethyl ether and water. The ether layer was then separated, dried over magnesium sulfate and concentrated under reduced pressure to give 58 gm of crude cyclohexylacetaldehyde.

後処理

  1. customThe reaction mixture was then partitioned between diethyl ether and water
  2. customThe ether layer was then separated
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-6041e0a3e87a40dd9d934a4c8934152b
出典データセット
uspto-grants-1992_10
特許番号
US05159081

反応ノート

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