3-[[(S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-oxo-3-phenylpropyl]amino]propanoic acid, phenylmethyl ester → Boc-Phe-betaAla-OH

HRID 467355ノート

反応式

HRID 467355 の反応式
[NH:1]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([O:17]CC1C=CC=CC=1)=[O:16])=[O:11])[CH2:3][C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>CO.[Pd]>[NH:1]([C:25]([O:27][C:28]([CH3:31])([CH3:30])[CH3:29])=[O:26])[C@H:2]([C:10]([NH:12][CH2:13][CH2:14][C:15]([OH:17])=[O:16])=[O:11])[CH2:3][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 1

HCID 136862023-[[(S)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-1-oxo-3-phenylpropyl]amino]propanoic acid, phenylmethyl ester

生成物 1

HCID 14330680Boc-Phe-betaAla-OH

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

3.0 g Boc-Phe-βAla-OBzl was reduced in 50 ml MeOH in the presence of Pd-black as a catalyst, and this was followed by concentration; the resulting residue was dissolved in 30 ml AcOEt, after which it was crystallized with 0.80 ml CHA and collected by filtration.

後処理

  1. concentrationthis was followed by concentration
  2. dissolutionthe resulting residue was dissolved in 30 ml AcOEt
  3. customafter which it was crystallized with 0.80 ml CHA
  4. filtrationcollected by filtration

出典と根拠

ORDレコード
ord-d9e70b58f34e47899769f70bb4eb5d14
出典データセット
uspto-grants-1992_10
特許番号
US05159061

反応ノート

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