Dimethylformamide → 1-Bromo-4-(cyclopropylmethoxy)benzene

HRID 467461

反応式

HRID 467461 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([OH:8])=[CH:4][CH:3]=1.Cl[CH2:10][CH:11]1[CH2:13][CH2:12]1.C([O-])([O-])=O.[K+].[K+].CN(C=O)C>O>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH2:10][CH:11]2[CH2:13][CH2:12]2)=[CH:4][CH:3]=1

参加物

6

反応物 4

HCID 6228DimethylformamideHCID 78084-BromophenolHCID 11430Potassium CarbonateHCID 80013(Chloromethyl)cyclopropane

生成物 1

HCID 156257521-Bromo-4-(cyclopropylmethoxy)benzene

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

5.0 g (28.9 mmol) 4-bromophenol, 3.93 g (43.4 mmol) (chloromethyl)cyclopropane and 7.99 g (57.8 mmol) K2CO3 are added to 10 mL DMF and stirred at 80° C. over night. Afterwards the reaction mixture is diluted with water and extracted with DCM. The organic layer is dried with MgSO4, filtered and the solvent is removed in vacuo.

後処理

  1. extractionextracted with DCM
  2. dry with materialThe organic layer is dried with MgSO4
  3. filtrationfiltered
  4. customthe solvent is removed in vacuo

出典と根拠

ORDレコード
ord-e2a0d5eb27f54a2c8c9fae9d97057072
出典データセット
uspto-grants-2014_01
特許番号
US08623860B2

関連ノート

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