Hydrochloric Acid → HCID 72280550、化合物

HRID 467605ノート

反応式

HRID 467605 の反応式
Cl.[N:2]1([CH2:8][CH:9]=[CH:10][C:11]([OH:13])=O)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1.C(Cl)(=O)C([Cl:17])=O>ClCCl.CN(C)C=O>[N:2]1([CH2:8][CH:9]=[CH:10][C:11]([Cl:17])=[O:13])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3]1

参加物

6

反応物 3

HCID 313Hydrochloric AcidHCID 65578Oxalyl chlorideHCID 541093814-(1-Piperidinyl)-2-butenoic acid

生成物 1

HCID 72280550HCID 72280550、化合物

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide触媒HCID 6344Dichloromethane溶媒

実験手順

The HCl salt of 4-Piperidin-1-yl-but-2-enoic acid (250 mg, 1.48 mmol) was dissolved in dichloromethane (15 mL). Dimethylformamide (3 drops) was added. Oxalyl chloride (155 μL, 1.77 mmol) was added slowly and the reaction was stirred at room temperature for 1 hour. The mixture was concentrated under reduced pressure and the residue was used as is.

後処理

  1. concentrationThe mixture was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-e246df21010a418db268d45e7238ec4b
出典データセット
uspto-grants-2014_01
特許番号
US08623883B2

反応ノート

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