Methanol → N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine

HRID 467609ノート

反応式

HRID 467609 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16](F)=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8].[OH-:24].[Na+].[CH3:26]O>O>[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10]2[C:19]3[C:14](=[CH:15][C:16]([O:24][CH3:26])=[C:17]([N+:20]([O-:22])=[O:21])[CH:18]=3)[N:13]=[CH:12][N:11]=2)[CH:5]=[CH:6][C:7]=1[F:8]

参加物

5

反応物 3

HCID 887MethanolHCID 14798Sodium HydroxideHCID 10640649N-(3-chloro-4-fluorophenyl)-7-fluoro-6-nitroquinazolin-4-amine

生成物 1

HCID 21847811N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-nitroquinazolin-4-amine

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

反応条件

温度
70 °C

実験手順

(3-Chloro-4-fluoro-phenyl)-(7-fluoro-6-nitro-quinazolin-4-yl)-amine was suspended in 100 ml methanol and 2 ml 50% NaOH in water was added and the mixture was heated at 70° C. for 2 hours. The mixture was then poured into water and stirred vigorously for 30 minutes, then filtered and washed with water and dried under vacuum at 60° C. overnight to give 7.2 g of (3-Chloro-4-fluoro-phenyl)-(7-methoxy-6-nitro-quinazolin-4-yl)-amine.

後処理

  1. filtrationfiltered
  2. washwashed with water
  3. customdried under vacuum at 60° C. overnight

出典と根拠

ORDレコード
ord-3011111f867a4abba9a85f8de7c690da
出典データセット
uspto-grants-2014_01
特許番号
US08623883B2

反応ノート

読み込み中…