[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[NH:9][C:10](=[S:19])[NH:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:4][CH:3]=1.[H-].[Na+].[H][H].[CH:24](Br)([CH3:26])[CH3:25]>CN(C)C=O.O>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[N:9]=[C:10]([S:19][CH:24]([CH3:26])[CH3:25])[NH:11][C:12]=2[C:13]2[CH:14]=[CH:15][N:16]=[CH:17][CH:18]=2)=[CH:6][CH:7]=1
To 8.0 g of 4-(4-fluorophenyl)-5-(4-pyridyl)-1H-imidazole-2-thione in 100 ml of dimethylformamide was added 1.56 g of sodium hydride (50% in mineral oil). The mixture was stirred until the evolution of hydrogen ceased. At this point 3.9 g of isopropyl bromide was added with a syringe. After stirring for 3 hours the mixture was poured into water, filtered and air dried. Trituration with ether, filtering and drying gave 5.73 g. Recrystallizing a 3.0 g sample from ethanol gave 1.4 g of the title compound, m.p. 263°-264°.
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