N,1-dimethyl-4-nitropyrazole-3-carboxamide → 4-amino-N,1-dimethyl-1H-pyrazole-3-carboxamide

HRID 467636ノート

反応式

HRID 467636 の反応式
[CH3:1][NH:2][C:3]([C:5]1[C:9]([N+:10]([O-])=O)=[CH:8][N:7]([CH3:13])[N:6]=1)=[O:4]>C(O)C.[Pd]>[CH3:1][NH:2][C:3]([C:5]1[C:9]([NH2:10])=[CH:8][N:7]([CH3:13])[N:6]=1)=[O:4]

参加物

4

反応物 1

HCID 1256475N,1-dimethyl-4-nitropyrazole-3-carboxamide

生成物 1

HCID 70175484-amino-N,1-dimethyl-1H-pyrazole-3-carboxamide収率 98.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

A solution of 1-methyl-4-nitro-1H-pyrazole-3-carboxylic acid methylamide (100 mg, 0.5 mmol) in ethanol (4 ml) was flushed with argon and treated with Pd/C 10% (40 mg, 0.04 mmol). The reaction vessel was evacuated and flushed with hydrogen three times and the reaction was stirred at ambient temperature overnight. The reaction mixture was filtrated and the solvent was evaporated to yield a brown viscous oil (76 mg, 91%) which was used without further purification.

後処理

  1. customThe reaction vessel was evacuated
  2. customflushed with hydrogen three times
  3. filtrationThe reaction mixture was filtrated
  4. customthe solvent was evaporated

出典と根拠

ORDレコード
ord-c17cc36d9b1b46f3930bbbec2e24b147
出典データセット
uspto-grants-2014_01
特許番号
US08623866B2

反応ノート

読み込み中…