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Water → Ethyl 2-p-chlorophenyl-5-(2,5-dimethylphenoxy)-4-oxazoleacetate

HRID 46769
ノート
印刷プレビュー

反応式

HRID 46769 の反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([O:17][C:18]3[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=3[CH3:25])=[C:11]([CH2:13][C:14]([OH:16])=[O:15])[N:12]=2)=[CH:4][CH:3]=1.[CH2:26](N(CC)CC)[CH3:27].C(Br)C.O>CN(C)C=O.C(OCC)(=O)C>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]([O:17][C:18]3[CH:23]=[C:22]([CH3:24])[CH:21]=[CH:20][C:19]=3[CH3:25])=[C:11]([CH2:13][C:14]([O:16][CH2:26][CH3:27])=[O:15])[N:12]=2)=[CH:4][CH:3]=1
参加物実験手順後処理出典と根拠反応ノート

参加物

7

反応物 4

HCID 962WaterHCID 6332Ethyl BromideHCID 8471TriethylamineHCID 203856742-p-Chlorophenyl-5-(2,5-dimethylphenoxy)-4-oxazoleacetic acid

生成物 1

HCID 20385693Ethyl 2-p-chlorophenyl-5-(2,5-dimethylphenoxy)-4-oxazoleacetate

試薬・触媒・溶媒 2

HCID 6228Dimethylformamide
溶媒
HCID 8857Ethyl Acetate溶媒

実験手順

To a solution of 0.80 g of 2-p-chlorophenyl-5-(2,5-dimethylphenoxy)-4-oxazoleacetic acid in 8 ml of dimethylformamide were added 1 ml of triethylamine and 1.5 ml of ethyl bromide. The mixture was stirred at 35°-40° C. for 90 minutes. The reaction mixture was poured into water and ethyl acetate and shaken with a separate funnel. The organic layer was successively washed with water, diluted hydrochloric acid and water, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The white crystalline residue was recrystallized from n-hexane to give 0.68 g of the title compound as white fine needles, melting at 122°-123.5° C.

後処理

  1. stirringshaken with a separate funnel
  2. washThe organic layer was successively washed with water, diluted hydrochloric acid and water
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentrated under reduced pressure
  5. customThe white crystalline residue was recrystallized from n-hexane

出典と根拠

ORDレコード
ord-78d5fb0f79924ff3ba2378b92fb05498
出典データセット
uspto-grants-1979_11
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US04175130

反応ノート

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