N-(2-Hydroxy-2-methylpropyl)-1-methyl-4-nitro-1H-pyrazole-3-carboxamide → 4-Amino-N-(2-hydroxy-2-methylpropyl)-1-methyl-1H-pyrazole-3-carboxamide

HRID 467719ノート

反応式

HRID 467719 の反応式
[OH:1][C:2]([CH3:17])([CH3:16])[CH2:3][NH:4][C:5]([C:7]1[C:11]([N+:12]([O-])=O)=[CH:10][N:9]([CH3:15])[N:8]=1)=[O:6]>C(O)C.[Pd]>[NH2:12][C:11]1[C:7]([C:5]([NH:4][CH2:3][C:2]([OH:1])([CH3:16])[CH3:17])=[O:6])=[N:8][N:9]([CH3:15])[CH:10]=1

参加物

4

反応物 1

HCID 70115746N-(2-Hydroxy-2-methylpropyl)-1-methyl-4-nitro-1H-pyrazole-3-carboxamide

生成物 1

HCID 653557454-Amino-N-(2-hydroxy-2-methylpropyl)-1-methyl-1H-pyrazole-3-carboxamide収率 99.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of N-(2-hydroxy-2-methylpropyl)-1-methyl-4-nitro-1H-pyrazole-3-carboxamide (391 mg, 1.61 mmol) in ethanol was added under an argon atmosphere Pd/C 10% (40 mg, 0.04 mmol) at ambient temperature. The mixture was stirred at that temperature under a hydrogen atmosphere for 16 hours. The catalyst was filtered off and washed with ethanol. The filtrate was concentrated in vacuo to give the title compound as waxy solid (340 mg, 99% yield) which was used without any further purification.

後処理

  1. filtrationThe catalyst was filtered off
  2. washwashed with ethanol
  3. concentrationThe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-bd70741b7c8042e88648159ac52f0d46
出典データセット
uspto-grants-2014_01
特許番号
US08623866B2

反応ノート

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