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Hydrochloric Acid → 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Hydrochloric Acid | HCID 313 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid ethyl ester | HCID 70126398 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 3-{[6-Cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid | HCID 70098928 | — |
反応手順
To a stirred suspension of 3-{[6-cyclopropyl-3-(pyrimidin-5-ylamino)-pyrazine-2-carbonyl]-amino}-isonicotinic acid ethyl ester (972 mg, 2.4 mmol) at rt in ethanol (15 ml) under an argon atmosphere was added 1 N NaOH (3 ml, 3.0 mmol). The suspension was stirred at rt for overnight. After the addition of 1 N HCl (3 ml) stirring was continued for 1 hr. The solid was collected by filtration, washed with H2O, then EtOH and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08623866B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-7a8520138c0d4080acfd81771d0a6e02 |
| 出典メモ | uspto-grants-2014_01 |