2-Methoxyethylamine → Ethyl 5-bromo-2-((2-methoxyethyl)amino)pyrimidine-4-carboxylate
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:11]([Br:12])=[CH:10][N:9]=[C:8](S(C)(=O)=O)[N:7]=1)=[O:5])[CH3:2].[CH3:17][O:18][CH2:19][CH2:20][NH2:21]>ClCCl>[CH2:1]([O:3][C:4]([C:6]1[C:11]([Br:12])=[CH:10][N:9]=[C:8]([NH:21][CH2:20][CH2:19][O:18][CH3:17])[N:7]=1)=[O:5])[CH3:2]参加物
4
反応条件
- 温度
- 45 °C
実験手順
A solution of 5-bromo-2-methanesulfonyl-pyrimidine-4-carboxylic acid ethyl ester (86 mg, 0.27 mmol) in dichloromethane (2 ml) was treated with 2-methoxyethylamine (124 μl, 1.44 mmol) under argon atmosphere and heated to 45° C. for 2 h. All volatiles were removed and the product was obtained after purification by silica gel chromatography using a heptane/ethyl acetate gradient as colorless oil (72 mg, 82%).
後処理
- customAll volatiles were removed
- customthe product was obtained
- customafter purification by silica gel chromatography
出典と根拠
- ORDレコード
- ord-b0ffabf93b3540b7b562b86c74e247f1
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08623866B2
反応ノート
読み込み中…