N-phenethyl-N-propyl-3,4-dimethoxyphenethylamine → 4-{2-[(2-Phenylethyl)(propyl)amino]ethyl}benzene-1,2-diol
反応式
[CH2:1]([N:9]([CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([O:21]C)=[C:17]([O:23]C)[CH:16]=1)[CH2:10][CH2:11][CH3:12])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>Br>[CH2:1]([N:9]([CH2:13][CH2:14][C:15]1[CH:20]=[CH:19][C:18]([OH:21])=[C:17]([OH:23])[CH:16]=1)[CH2:10][CH2:11][CH3:12])[CH2:2][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][CH:8]=1参加物
3
実験手順
A solution of 9.37 g of the product of Step B in 90 ml of 48% hydrobromic acid was refluxed for 3 hours under a nitrogen atmosphere and was then evaporated to dryness. The residue was taken up in 50 ml of ammonium hydroxide solution and the solution was extracted with methylene chloride. The organic extracts were washed with water, dried over magnesium sulfate, filtered and evaporated to dryness to obtain 8.1 g of N-phenethyl-N-propyl-3,4-dihydroxyphenethylamine in the form of a reddish oil.