Ethyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate → 1H-Pyrazole-5-carboxylic acid, 4-amino-1-methyl-, ethyl ester

HRID 467768ノート

反応式

HRID 467768 の反応式
[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:14])[N:8]=[CH:9][C:10]=1[N+:11]([O-])=O)=[O:5])[CH3:2]>CCO.[Pd]>[CH2:1]([O:3][C:4]([C:6]1[N:7]([CH3:14])[N:8]=[CH:9][C:10]=1[NH2:11])=[O:5])[CH3:2]

参加物

4

反応物 1

HCID 59812796Ethyl 1-methyl-4-nitro-1H-pyrazole-5-carboxylate

生成物 1

HCID 601364511H-Pyrazole-5-carboxylic acid, 4-amino-1-methyl-, ethyl ester収率 97.4%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a solution of 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid ethyl ester (1.97 g, 9.89 mmol; prepared from 2-methyl-4-nitro-2H-pyrazole-3-carboxylic acid according to WO 2009/026241) in EtOH (20 ml) under argon atmosphere was added 10% Pd/C (200 mg). The black suspension was stirred at r.t. under a hydrogen atmosphere for 20 h. The catalyst was filtered off and washed with EtOH. The product was obtained upon evaporation as light brown oil (1.63 g, 97%) and used without further purification.

後処理

  1. filtrationThe catalyst was filtered off
  2. washwashed with EtOH

出典と根拠

ORDレコード
ord-651ee2a375734bbe8b3d072a67904658
出典データセット
uspto-grants-2014_01
特許番号
US08623866B2

反応ノート

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