Lithium iodide → HCID 70099812、化合物
反応式
[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[C:18]([C:19]([O:21]C)=[O:20])=[C:17]([CH3:23])[C:16]([CH3:24])=[CH:15][CH:14]=3)=[O:11])[C:7]([NH:25][C:26]3[CH:27]=[N:28][CH:29]=[N:30][CH:31]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1.[I-].[Li+]>N1C=CC=CC=1>[CH:1]1([C:4]2[N:9]=[C:8]([C:10]([NH:12][C:13]3[C:18]([C:19]([OH:21])=[O:20])=[C:17]([CH3:23])[C:16]([CH3:24])=[CH:15][CH:14]=3)=[O:11])[C:7]([NH:25][C:26]3[CH:27]=[N:28][CH:29]=[N:30][CH:31]=3)=[N:6][CH:5]=2)[CH2:3][CH2:2]1参加物
4
実験手順
To a solution of methyl 6-(6-cyclopropyl-3-(pyrimidin-5-ylamino)pyrazine-2-carboxamido)-2,3-dimethylbenzoate (0.05 g, 119 μmol) in pyridine (1 ml) at r.t under an argon atmosphere was added lithium iodide (125 mg, 932 μmol). The mixture was heated at 100° for 16 hr. The solvent was evaporated. The crude product was used directly in the next step.
後処理
- temperatureThe mixture was heated at 100° for 16 hr