4-Phenoxyphenol → 2-(4-Phenoxyphenoxy)cyclopentan-1-ol

HRID 46781

反応式

HRID 46781 の反応式
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I-].C([NH+]([CH2:21][CH3:22])CC)C>C(Cl)(Cl)Cl>[O:1]([C:8]1[CH:9]=[CH:10][C:11]([O:14][CH:22]2[CH2:21][CH2:4][CH2:3][CH:2]2[OH:1])=[CH:12][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

参加物

4

反応物 2

HCID 132544-PhenoxyphenolHCID 3014304Triethylammonium iodide

生成物 1

HCID 222476762-(4-Phenoxyphenoxy)cyclopentan-1-ol

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

反応条件

温度
150 °C

実験手順

A mixture of 18.6 g of 4-phenoxyphenol, 12.8 g of 1,2-carbonyldioxycyclopentane and 4.6 g of triethylammonium iodide is stirred for 7 hours at 150° C. After cooling, the reaction mixture is taken up in chloroform. The solution is washed with water and once with saturated sodium chloride solution, dried over sodium sulphate and concentrated by rotary evaporation. Fractional distillation of the residue yields (2-(4-phenoxyphenoxy)-cyclopentan-1-ol as a colourless oil with a melting point of 181°-185° C./0.001 torr.

後処理

  1. temperatureAfter cooling
  2. washThe solution is washed with water and once with saturated sodium chloride solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated by rotary evaporation
  5. distillationFractional distillation of the residue

出典と根拠

ORDレコード
ord-548d1b3741fe4d498d99cad709f385ba
出典データセット
uspto-grants-1979_11
特許番号
US04175137

関連ノート

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