1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione → 5-amino-1,3-dimethylpyrimidine-2,4(1h,3h)-dione

HRID 467848ノート

反応式

HRID 467848 の反応式
[CH3:1][N:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[C:5](=[O:11])[N:4]([CH3:12])[C:3]1=[O:13]>CO.[Pd]>[NH2:8][C:6]1[C:5](=[O:11])[N:4]([CH3:12])[C:3](=[O:13])[N:2]([CH3:1])[CH:7]=1

参加物

4

反応物 1

HCID 963701,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione

生成物 1

HCID 2507115-amino-1,3-dimethylpyrimidine-2,4(1h,3h)-dione収率 89.5%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a stirred solution of 1,3-dimethyl-5-nitropyrimidine-2,4(1H,3H)-dione (2.0 g, 10.802 mmol) in methanol (200 mL), 10% Pd—C (0.500 g) was added under hydrogen atmosphere and the reaction mixture was stirred at room temperature for 2 h. Reaction mixture was filtered through a celite bed and washed with methanol. The filtrate was collected and concentrated under reduced pressure to give 1.5 g of the product.

後処理

  1. customReaction mixture
  2. filtrationwas filtered through a celite bed
  3. washwashed with methanol
  4. customThe filtrate was collected
  5. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-46ace8368cce48f2bc6e86dd744856fa
出典データセット
uspto-grants-2014_01
特許番号
US08623880B2

反応ノート

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