Fluprostenol → HCID 178459549、化合物

HRID 468035

反応式

HRID 468035 の反応式
[CH2:1]1[C@@H:5]([OH:6])[C@H:4](/[CH:7]=[CH:8]/[C@@H:9]([OH:22])[CH2:10][O:11][C:12]2[CH:17]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:15]=[CH:14][CH:13]=2)[C@@H:3]([CH2:23]/[CH:24]=[CH:25]\[CH2:26][CH2:27][CH2:28][C:29]([OH:31])=[O:30])[C@H:2]1[OH:32].[NH2:33][C@H:34]([C:42]([OH:44])=[O:43])[CH2:35][CH2:36][CH2:37][NH:38][C:39](=[NH:41])[NH2:40]>CO.O>[CH3:35][CH:34]([O:30][C:29]([CH2:28][CH2:27][CH2:26]/[CH:25]=[CH:24]\[CH2:23][C@@H:3]1[C@@H:4](/[CH:7]=[CH:8]/[C@@H:9]([OH:22])[CH2:10][O:11][C:12]2[CH:13]=[CH:14][CH:15]=[C:16]([C:18]([F:21])([F:20])[F:19])[CH:17]=2)[C@H:5]([OH:6])[CH2:1][C@@H:2]1[OH:32])=[O:31])[CH3:42].[NH2:33][C@H:34]([C:42]([OH:44])=[O:43])[CH2:35][CH2:36][CH2:37][NH:38][C:39](=[NH:40])[NH2:41]

参加物

4

反応物 2

HCID 5311100FluprostenolHCID 178418600HCID 178418600、化合物

生成物 1

HCID 178459549HCID 178459549、化合物

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

実験手順

To travoprost free acid ((+)-fluprostenol free acid) 3 in MeOH/H2O was added L-Arginine (>98%) (Sigma-Aldrich Cat. A5006) and the solution was stirred for 30 minutes. The solvents were evaporated then azeotroped with Et2O and hexanes to give white crystalline travoprost-L-Arginine salt 4 (quantitative).

後処理

  1. customThe solvents were evaporated
  2. customthen azeotroped with Et2O and hexanes

出典と根拠

ORDレコード
ord-62aebbbdd09a41f4866fa8fbcec861cb
出典データセット
uspto-grants-2014_01
特許番号
US08623918B2

関連ノート

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