Diallyl Disulfide → Allicin

10 ml of diallyl disulphide (DADS) were stirred into 100 ml ethanol/water (1:1). 20 grams of potassium peroxymonosulfate (Oxone®) was added slowly over 2 hours, and stirred at below 10° C. until no further reaction was observed. The resultant solution was then filtered, and then extracted with diethyl ether (2×50 ml). The diethyl ether layers were combined and washed with 10% brine solution 2×50 ml. The ether layer was dried with magnesium sulfate then reduced to under vacuum. Removal of the solvent produced a yellow oil of pure allicin better than 90% (expressed as a % of pure material). The pure allicin may then be treated as per Example 1 for conversion to ajoene.

1. filtrationThe resultant solution was then filtered
2. extractionextracted with diethyl ether (2×50 ml)
3. washwashed with 10% brine solution 2×50 ml
4. dry with materialThe ether layer was dried with magnesium sulfate
5. customRemoval of the solvent

ORDレコード

ord-f08523db7f32422489394b230990a836

出典データセット

uspto-grants-2014_01

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US08623923B2