1,1'-Carbonyldiimidazole → HCID 59625974、化合物

HRID 468179ノート

反応式

HRID 468179 の反応式
[NH2:1][C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][C:11]=1[NH:12][C:13]1[CH:18]=[CH:17][C:16]([F:19])=[CH:15][CH:14]=1)[C:5]([O:7][CH3:8])=[O:6].[C:20](N1C=CN=C1)(N1C=CN=C1)=[O:21]>CN(C=O)C>[F:19][C:16]1[CH:17]=[CH:18][C:13]([N:12]2[C:11]3[CH:10]=[CH:9][C:4]([C:5]([O:7][CH3:8])=[O:6])=[CH:3][C:2]=3[NH:1][C:20]2=[O:21])=[CH:14][CH:15]=1

参加物

4

反応物 2

HCID 682631,1'-CarbonyldiimidazoleHCID 59625705HCID 59625705、化合物

生成物 1

HCID 59625974HCID 59625974、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
90 °C

実験手順

A mixture of 60d (0.20 g, 0.826 mmol) and 1,1′-carbonyldiimidazole (0.535 g, 3.3 mmol) in DMF (8 mL) was heated at 90° C. for 2 h. The solvent was removed and the residue was triturated with water (15 mL). The resulting precipitate was collected by filtration and washed several times with water. The crude product 60i was used in the next reaction without further purification. MS m/z (M+H+) 287.1.

後処理

  1. customThe solvent was removed
  2. customthe residue was triturated with water (15 mL)
  3. filtrationThe resulting precipitate was collected by filtration
  4. washwashed several times with water
  5. customThe crude product 60i was used in the next reaction without further purification

出典と根拠

ORDレコード
ord-fce9c37bc6cb438d9f05cbaa5259d84a
出典データセット
uspto-grants-2014_01
特許番号
US08623858B2

反応ノート

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