Sodium Hydroxide → 3-Chloro-2,2-dimethylbut-3-enoic acid
反応式
[Cl:1][C:2](=[CH2:10])[C:3]([CH3:9])([CH3:8])[C:4]([O:6]C)=[O:5].[OH-].[Na+]>O>[Cl:1][C:2](=[CH2:10])[C:3]([CH3:9])([CH3:8])[C:4]([OH:6])=[O:5]参加物
4
実験手順
A mixture of methyl 3-chloro-2,2-dimethylbut-3-enoate (42.0 g, 0.26 mol) and NaOH (12.4 g, 031 mol) in water (300 mL) was heated at reflux overnight. After cooling, the reaction mixture was extracted with ether. The organic layer contained 20 g of methyl 3-chloro-2,2-dimethylbut-3-enoate (48% recovered). The aqueous layer was acidified with cold 20% HCl solution and was extracted with ether (250 mL×3). The combined organic layers were dried and evaporated under reduced pressure to give 3-chloro-2,2-dimethylbut-3-enoic acid (17 g, 44%), which was used directly in the next step.
後処理
- temperaturewas heated
- temperatureat reflux overnight
- temperatureAfter cooling
- extractionthe reaction mixture was extracted with ether
- extractionwas extracted with ether (250 mL×3)
- customThe combined organic layers were dried
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-c673632a67c3427986008d179b470cd2
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08623905B2
反応ノート
読み込み中…