Pyridine → 4-(1-bromoethyl)-N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)benzamide

HRID 468771ノート

反応式

HRID 468771 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][C:5]([CH3:24])=[C:6]([C:8]2[CH:17]=[C:16]3[C:11]([CH:12]=[C:13]([NH:18][C:19]([CH:21]4[CH2:23][CH2:22]4)=[O:20])[N:14]=[CH:15]3)=[CH:10][CH:9]=2)[CH:7]=1.N1C=CC=CC=1.[Br:31][CH:32]([C:34]1[CH:42]=[CH:41][C:37]([C:38](Cl)=[O:39])=[CH:36][CH:35]=1)[CH3:33]>ClCCl>[Br:31][CH:32]([C:34]1[CH:42]=[CH:41][C:37]([C:38]([NH:1][C:2]2[CH:3]=[CH:4][C:5]([CH3:24])=[C:6]([C:8]3[CH:17]=[C:16]4[C:11]([CH:12]=[C:13]([NH:18][C:19]([CH:21]5[CH2:22][CH2:23]5)=[O:20])[N:14]=[CH:15]4)=[CH:10][CH:9]=3)[CH:7]=2)=[O:39])=[CH:36][CH:35]=1)[CH3:33]

参加物

5

反応物 3

HCID 1049PyridineHCID 67974803N-(7-(5-amino-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamideHCID 866749384-(1-Bromoethyl)benzoyl chloride

生成物 1

HCID 866749394-(1-bromoethyl)-N-(3-(3-(cyclopropanecarboxamido)isoquinolin-7-yl)-4-methylphenyl)benzamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒2 回

実験手順

To a solution of N-(7-(5-amino-2-methylphenyl)isoquinolin-3-yl)cyclopropanecarboxamide (51.8 mg, 0.163 mmol) and pyridine (0.05 mL, 0.6 mmol) in 2 mL dichloromethane was added a solution of the residue from Step 1 in 2 mL dichloromethane. The resulting mixture was stirred at room temperature for 1.5 hours, and then carried forward without purification.

後処理

  1. customcarried forward without purification

出典と根拠

ORDレコード
ord-96f39c5e93524d099839f12765c88f15
出典データセット
uspto-grants-2014_01
特許番号
US08623889B2

反応ノート

読み込み中…