Ammonium Hydroxide → 2-Amino-4-chloropyrimidine
反応式
[Cl:1][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[OH-].[NH4+:10]>>[NH2:10][C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.[Cl:1][C:2]1[N:7]=[C:6]([NH2:10])[CH:5]=[CH:4][N:3]=1参加物
4
実験手順
To 2,4-Dichloropyrimidine (1.0 g, 6.7 mmol) was added 28% w/v ammonium hydroxide solution (20 mL). The mixture was stirred overnight at ambient temperature then concentrated in vacuo. The residue was dry loaded and purified by FCC eluting with 2-10% EtOH in CHCl3 to afford 2-amino-4-chloropyrimidine and 2-chloro-4-aminopyrimidine.
後処理
- concentrationthen concentrated in vacuo
- customThe residue was dry loaded
- custompurified by FCC
- washeluting with 2-10% EtOH in CHCl3
出典と根拠
- ORDレコード
- ord-20a8d0fd8cdf4fd5ae501cd05436ce51
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08623859B2
反応ノート
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