1,1'-Carbonyldiimidazole → 4-methoxy-N,2,6-trimethyl-N-[(4-{[4-(2-pyridin-4-ylethyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide

HRID 469011

反応式

HRID 469011 の反応式
[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21](O)=[O:22])[CH:17]=2)[CH3:14])(=[O:12])=[O:11])=[C:5]([CH3:24])[CH:4]=1.C1N=CN(C(N2C=NC=C2)=O)C=1.[N:37]1[CH:42]=[CH:41][C:40]([CH2:43][CH2:44][N:45]2[CH2:50][CH2:49][NH:48][CH2:47][CH2:46]2)=[CH:39][CH:38]=1>ClCCCl>[CH3:1][O:2][C:3]1[CH:8]=[C:7]([CH3:9])[C:6]([S:10]([N:13]([CH3:14])[CH2:15][C:16]2[O:20][CH:19]=[C:18]([C:21]([N:48]3[CH2:49][CH2:50][N:45]([CH2:44][CH2:43][C:40]4[CH:39]=[CH:38][N:37]=[CH:42][CH:41]=4)[CH2:46][CH2:47]3)=[O:22])[CH:17]=2)(=[O:11])=[O:12])=[C:5]([CH3:24])[CH:4]=1

参加物

5

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 5586851-[2-(4-Pyridinyl)ethyl]piperazineHCID 583930975-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid

生成物 1

HCID 583933154-methoxy-N,2,6-trimethyl-N-[(4-{[4-(2-pyridin-4-ylethyl)piperazin-1-yl]carbonyl}furan-2-yl)methyl]benzenesulfonamide

試薬・触媒・溶媒 1

HCID 111,2-Dichloroethane溶媒

実験手順

The title compound was prepared according to general procedure AA using 5-({[(4-Methoxy-2,6-dimethylphenyl)sulfonyl](methyl)amino}methyl)furan-3-carboxylic acid (63 mg, 0.18 mmol), CDI (58 mg, 0.36 mmol) and 1-[2-(pyridin-4-yl)ethyl]piperazine (57 mg, 0.30 mmol) in DCE (4.5 mL). The crude product was purified using Ambersep and PL-MIA resins, then using prep method A.

後処理

  1. customThe crude product was purified

出典と根拠

ORDレコード
ord-9acf8c69bcc94a6fa68e800f138f8ff0
出典データセット
uspto-grants-2014_01
特許番号
US08623859B2

関連ノート

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