Ammonia → 2,6-Dichloro-5-nitropyrimidin-4-amine

HRID 469183

反応式

HRID 469183 の反応式
[Cl:1][C:2]1[N:7]=[C:6](Cl)[C:5]([N+:9]([O-:11])=[O:10])=[C:4]([Cl:12])[N:3]=1.CC[N:15](CC)CC.N>C1COCC1>[NH2:15][C:6]1[N:7]=[C:2]([Cl:1])[N:3]=[C:4]([Cl:12])[C:5]=1[N+:9]([O-:11])=[O:10]

参加物

5

反応物 3

HCID 222AmmoniaHCID 8471TriethylamineHCID 42978432,4,6-Trichloro-5-nitropyrimidine

生成物 1

HCID 3508112,6-Dichloro-5-nitropyrimidin-4-amine

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

A solution of 2,4,6-trichloro-5-nitropyrimidine (94 mg, 0.413 mmol) in THF (5 mL) was cooled to −78° C. and treated with Et3N (110 μL, 0.757 mmol), followed by NH3 (7 N in MeOH, 50 μL, 0.344 mmol). The reaction was warmed to 0° C. Once TLC indicated complete consumption of the starting material, the crude product solution was immediately used in the reaction below (Scheme 40).

後処理

  1. customconsumption of the starting material
  2. customthe crude product solution was immediately used in the reaction below (Scheme 40)

出典と根拠

ORDレコード
ord-78d78ece27574972ab7b607ff3724d01
出典データセット
uspto-grants-2014_01
特許番号
US08629142B2

関連ノート

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