Thionyl Chloride → 5-Bromo-nicotinic acid chloride hydrochloride

HRID 469325ノート

反応式

HRID 469325 の反応式
[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:13])=O>>[ClH:13].[Br:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([Cl:13])=[O:8]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 887075-Bromonicotinic acid

生成物 1

HCID 189717365-Bromo-nicotinic acid chloride hydrochloride

実験手順

2.00 g (9.90 mmol) 5-bromonicotinic acid were mixed with 20 mL thionyl chloride and boiled for 4 h. The mixture was evaporated to dryness i. vac. and coevaporated twice with toluene. The residue was reacted further as the crude product.

後処理

  1. customThe mixture was evaporated to dryness i
  2. customThe residue was reacted further as the crude product

出典と根拠

ORDレコード
ord-aec1b31938f64749be5586e273bf77b8
出典データセット
uspto-grants-2014_01
特許番号
US08629137B2

反応ノート

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