Thionyl Chloride → 3-Bromo-4-fluorobenzoyl chloride

HRID 469332ノート

反応式

HRID 469332 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](O)=[O:6].S(Cl)([Cl:14])=O>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([Cl:14])=[O:6]

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 705093-Bromo-4-fluorobenzoic acid

生成物 1

HCID 695983-Bromo-4-fluorobenzoyl chloride

実験手順

2.17 g (9.41 mmol) 3-bromo-4-fluorobenzoic acid were mixed with 20 mL thionyl chloride and then boiled for 2 h. The reaction mixture was evaporated to dryness and coevaporated twice with toluene. The residue was reacted further as the crude product.

後処理

  1. customThe reaction mixture was evaporated to dryness
  2. customThe residue was reacted further as the crude product

出典と根拠

ORDレコード
ord-b8ace32349b54da58a96b7c11a9daa56
出典データセット
uspto-grants-2014_01
特許番号
US08629137B2

反応ノート

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