3-Bromo-4-fluorobenzoyl chloride → 6-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one

HRID 469333

反応式

HRID 469333 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5](Cl)=[O:6].[CH3:12][C:13]1[C:18]2[NH:19][C:20](=[O:22])[O:21][C:17]=2[CH:16]=[CH:15][CH:14]=1.[Cl-].[Cl-].[Cl-].[Al+3]>>[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[F:11])[C:5]([C:15]1[CH:14]=[C:13]([CH3:12])[C:18]2[NH:19][C:20](=[O:22])[O:21][C:17]=2[CH:16]=1)=[O:6]

参加物

4

反応物 3

HCID 695983-Bromo-4-fluorobenzoyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 127093364-Methyl-3H-benzooxazol-2-one

生成物 1

HCID 581811656-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one

実験手順

2.23 g (9.40 mmol) 3-bromo-4-fluoro-benzoic acid chloride, 1.40 g (9.40 mmol) 4-methyl-3H-benzoxazol-2-one and 5.01 g (37.60 mmol) aluminium trichloride were heated to 125° C. for 1.5 h with stirring. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered and washed with water. Then the precipitate was triturated with MeOH, suction filtered, washed with MeOH and dried i. vac.

後処理

  1. customThe precipitate formed
  2. filtrationfiltered
  3. washwashed with water
  4. customThen the precipitate was triturated with MeOH, suction
  5. filtrationfiltered
  6. washwashed with MeOH
  7. customdried i

出典と根拠

ORDレコード
ord-f0500187676c41158cfad604f0265059
出典データセット
uspto-grants-2014_01
特許番号
US08629137B2

関連ノート

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