化工社化工社 化学情報印刷レポート · 研究参考用
3-Bromo-4-fluorobenzoyl chloride → 6-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Bromo-4-fluorobenzoyl chloride | HCID 69598 | — |
| 反応物 | Aluminum(III) Chloride | HCID 6451240 | — |
| 反応物 | 4-Methyl-3H-benzooxazol-2-one | HCID 12709336 | — |
| 生成物 | 6-(3-bromo-4-fluoro-benzoyl)-4-methyl-3H-benzoxazol-2-one | HCID 58181165 | — |
反応手順
2.23 g (9.40 mmol) 3-bromo-4-fluoro-benzoic acid chloride, 1.40 g (9.40 mmol) 4-methyl-3H-benzoxazol-2-one and 5.01 g (37.60 mmol) aluminium trichloride were heated to 125° C. for 1.5 h with stirring. After cooling to RT the mixture was mixed with ice water. The precipitate formed was suction filtered and washed with water. Then the precipitate was triturated with MeOH, suction filtered, washed with MeOH and dried i. vac.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08629137B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-f0500187676c41158cfad604f0265059 |
| 出典メモ | uspto-grants-2014_01 |