7-Methylisatin → 2H-Indol-2-one, 1,3-dihydro-7-methyl-

HRID 469358

反応式

HRID 469358 の反応式
[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[C:7]2=O.O.NN>>[CH3:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:10]=1[NH:9][C:8](=[O:11])[CH2:7]2

参加物

3

反応物 2

HCID 143137-MethylisatinHCID 24654Hydrazine hydrate (1:1)

生成物 1

HCID 30142252H-Indol-2-one, 1,3-dihydro-7-methyl-

実験手順

5.00 g (31.0 mmol) 7-methyl-1H-indol-2,3-dione in 18.1 mL (372 mmol) hydrazine hydrate were heated to 110° C. for 3 h. Then the reaction mixture was cooled, the precipitate formed was suction filtered and washed with water. The precipitate was suspended in water, acidified with conc. hydrochloric acid and stirred for 10 min. Then the reaction mixture was stirred for a further 30 min in the ice bath, the precipitate was suction filtered, washed with water and dried.

後処理

  1. temperatureThen the reaction mixture was cooled
  2. customthe precipitate formed
  3. filtrationfiltered
  4. washwashed with water
  5. stirringThen the reaction mixture was stirred for a further 30 min in the ice bath
  6. filtrationfiltered
  7. washwashed with water
  8. customdried

出典と根拠

ORDレコード
ord-359fa9febe914ddb907f15fe88f97ad9
出典データセット
uspto-grants-2014_01
特許番号
US08629137B2

関連ノート

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