Glyoxylic Acid → 4-Hydroxyphenylglycine

HRID 46942

反応式

HRID 46942 の反応式
[C:1]([OH:5])(=[O:4])[CH:2]=O.C([O-])(=O)C.[NH4+:10].[C:11]1([OH:17])[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1>O>[CH:13]1[C:14]([CH:2]([NH2:10])[C:1]([OH:5])=[O:4])=[CH:15][CH:16]=[C:11]([OH:17])[CH:12]=1

参加物

5

反応物 3

HCID 760Glyoxylic AcidHCID 996PhenolHCID 517165Ammonium Acetate

生成物 1

HCID 921434-Hydroxyphenylglycine収率 28.9%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

30 g of an aqueous 40% glyoxylic acid solution are added to 70 ml of water, and 37.5 g of ammonium acetate and 22.5 g of phenol are added thereto under stirring. The mixture is stirred at room temperature for 41 hours. The crystalline precipitates are collected by filtration under cooling, and then successively washed with water and methanol. 7.8 g of DL-p-hydroxyphenylglycine are thereby obtained as white crystals. Yield: 28.9%, M.p. 225°-228° C. (decomp.).

後処理

  1. additionare added
  2. stirringThe mixture is stirred at room temperature for 41 hours
  3. customThe crystalline precipitates
  4. filtrationare collected by filtration
  5. temperatureunder cooling
  6. washsuccessively washed with water and methanol

出典と根拠

ORDレコード
ord-4a71fba6378949a183990fe45aff8c26
出典データセット
uspto-grants-1979_11
特許番号
US04175206

関連ノート

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