Methyl 3-amino-2-thiophenecarboxylate → HCID 58557000、化合物

HRID 469451ノート

反応式

HRID 469451 の反応式
C([C:3](Br)([C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)[C:4]([OH:6])=[O:5])C.[NH2:14][C:15]1[CH:19]=[CH:18][S:17][C:16]=1[C:20]([O:22][CH3:23])=[O:21]>C(#N)C>[CH3:23][O:22][C:20]([C:16]1[S:17][CH:18]=[CH:19][C:15]=1[NH:14][CH:3]([C:7]1[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1)[C:4]([OH:6])=[O:5])=[O:21]

参加物

4

反応物 2

HCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 19431595Ethyl 2-bromo-2-phenylacetic acid

生成物 1

HCID 58557000HCID 58557000、化合物

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A solution of ethyl 2-bromo-2-phenylacetic acid (600 mg, 2.79 mmol) and methyl 3-aminothiophene-2-carboxylate (438 mg, 2.79 mmol) in acetonitrile (20 ml) was heated under microwave irradiation at 100° C. for 1 hour. Acetonitrile was evaporated to dryness and the resulting residue was used in the next step without any further purification.

後処理

  1. customAcetonitrile was evaporated to dryness
  2. customthe resulting residue was used in the next step without any further purification

出典と根拠

ORDレコード
ord-2852a2337e8d4caaa243ffaee22e39b6
出典データセット
uspto-grants-2014_01
特許番号
US08629160B2

反応ノート

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