Phenylboronic Acid → HCID 58557000、化合物

HRID 469453ノート

反応式

HRID 469453 の反応式
[C:1]1(B(O)O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:10][C:11]1[CH:15]=[CH:14][S:13][C:12]=1[C:16]([O:18][CH3:19])=[O:17].O.O=[CH:22][C:23]([OH:25])=[O:24]>C(#N)C>[CH3:19][O:18][C:16]([C:12]1[S:13][CH:14]=[CH:15][C:11]=1[NH:10][CH:22]([C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1)[C:23]([OH:25])=[O:24])=[O:17]

参加物

5

反応物 3

HCID 66827Phenylboronic AcidHCID 89652Methyl 3-amino-2-thiophenecarboxylateHCID 15620607Glyoxylic acid, monohydrate

生成物 1

HCID 58557000HCID 58557000、化合物収率 82%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

A mixture of phenylboronic acid (286 mg, 2.35 mmol), methyl 3-aminothiophene-2-carboxylate (369 mg, 2.35 mmol), and 2-oxoacetic acid hydrate (216 mg, 2.35 mmol) in acetonitrile (20 ml) was stirred at room temperature for 2 hours. The reaction was filtered, and the precipitated was washed with little acetonitrile. The solution was concentrated under reduced pressure, and the precipitate was collected again by filtration, washing with little acetonitrile. The combined precipitates were dried under vacuum overnight to obtain 2-(2-(methoxycarbonyl)thiophen-3-ylamino)-2-phenylacetic acid (558 mg, 82% yield).

後処理

  1. filtrationThe reaction was filtered
  2. washthe precipitated was washed with little acetonitrile
  3. concentrationThe solution was concentrated under reduced pressure
  4. filtrationthe precipitate was collected again by filtration
  5. washwashing with little acetonitrile
  6. customThe combined precipitates
  7. customwere dried under vacuum overnight

出典と根拠

ORDレコード
ord-4ac5e791d35f477e9179ddd7d73f9299
出典データセット
uspto-grants-2014_01
特許番号
US08629160B2

反応ノート

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