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1-Adamantaneacetyl chloride → 2-(1-adamantyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1-Adamantaneacetyl chloride | HCID 2771882 | — |
| 反応物 | 2-amino-4-(trifluoromethyl)phthalazin-1(2H)-one | HCID 67161111 | — |
| 生成物 | 2-(1-adamantyl)-N-[1-oxo-4-(trifluoromethyl)phthalazin-2(1H)-yl]acetamide | HCID 67162587 | 77% |
反応手順
The product of Example 11B (50.6 mg) and (adamantan-1-yl)acetyl chloride (54 mg, 0.25 mmol) were treated as in Example 6 to give the title compound (69 mg, 0.17 mmol) as a white solid. 1H NMR (300 MHz, DMSO-d6) δ 11.47 (s, 1H), 8.44 (dd, 1H), 8.18-7.98 (m, 3H), 2.08 (s, 2H), 1.99-1.92 (m, 3H), 1.75-1.55 (m, 12H); MS (DCI) M/Z 423.3 (M+NH4)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08629143B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-06c8a61a7dd149cabe5a29f9e2bd3ad8 |
| 出典メモ | uspto-grants-2014_01 |