反応式
[NH2:1][N:2]1[N:11]=[C:10]([C:12]([F:15])([F:14])[F:13])[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:16].[Cl:17][C:18]1[S:22][C:21]([CH2:23][C:24](O)=[O:25])=[CH:20][CH:19]=1>>[Cl:17][C:18]1[S:22][C:21]([CH2:23][C:24]([NH:1][N:2]2[N:11]=[C:10]([C:12]([F:15])([F:13])[F:14])[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3]2=[O:16])=[O:25])=[CH:20][CH:19]=1参加物
3
実験手順
The product of Example 11B and 2-(5-chlorothiophen-2-yl)acetic acid were treated using a method similar to that described in Example 5 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.96-11.98 (bs, 1H), 8.43 (d, J=8.4 Hz, 1H), 8.11-8.17 (m, 1H), 7.97-8.10 (m, 2H), 7.01 (d, J=3.8 Hz, 1H), 6.93 (d, J=3.8 Hz, 1H), 3.96 (d, J=0.8 Hz, 2H); MS (ESI) m/z 388 (M+H)+.
出典と根拠
- ORDレコード
- ord-504f916a9ec141e880d3ab927e747ed1
- 出典データセット
- uspto-grants-2014_01
- 特許番号
- US08629143B2
関連ノート
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