2-(5-chlorothiophen-2-yl)acetic Acid → N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(5-chloro-2-thienyl)acetamide

HRID 469613

反応式

HRID 469613 の反応式
[NH2:1][N:2]1[N:11]=[C:10]([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[C:3]1=[O:19].[Cl:20][C:21]1[S:25][C:24]([CH2:26][C:27](O)=[O:28])=[CH:23][CH:22]=1>>[Cl:18][C:15]1[CH:16]=[CH:17][C:12]([C:10]2[C:9]3[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=3)[C:3](=[O:19])[N:2]([NH:1][C:27](=[O:28])[CH2:26][C:24]3[S:25][C:21]([Cl:20])=[CH:22][CH:23]=3)[N:11]=2)=[CH:13][CH:14]=1

参加物

3

反応物 2

HCID 44267162-(5-chlorothiophen-2-yl)acetic AcidHCID 671613672-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one

生成物 1

HCID 53238659N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(5-chloro-2-thienyl)acetamide

実験手順

The product of Example 86A and 2-(5-chlorothiophen-2-yl)acetic acid were treated using a method similar to that described in Example 5 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.77-11.81 (bs, 1H), 8.39-8.42 (m, 1H), 7.84-8.05 (m, 2H), 7.70-7.76 (m, 1H), 7.56-7.68 (m, 4H), 6.99 (d, J=3.8 Hz, 1H), 6.92 (d, J=3.8 Hz, 1H), 3.91-3.92 (bs, 2H); MS (ESI+) M/Z 430 (M+H)+.

出典と根拠

ORDレコード
ord-35fb7061da3e47c6b43a99cb207d06ed
出典データセット
uspto-grants-2014_01
特許番号
US08629143B2

関連ノート

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