化工社化工社 化学情報印刷レポート · 研究参考用
2-(5-chlorothiophen-2-yl)acetic Acid → N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(5-chloro-2-thienyl)acetamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-(5-chlorothiophen-2-yl)acetic Acid | HCID 4426716 | — |
| 反応物 | 2-amino-4-(4-chlorophenyl)phthalazin-1(2H)-one | HCID 67161367 | — |
| 生成物 | N-[4-(4-chlorophenyl)-1-oxophthalazin-2(1H)-yl]-2-(5-chloro-2-thienyl)acetamide | HCID 53238659 | — |
反応手順
The product of Example 86A and 2-(5-chlorothiophen-2-yl)acetic acid were treated using a method similar to that described in Example 5 to give the title compound. 1H NMR (300 MHz, DMSO-d6) δ ppm 11.77-11.81 (bs, 1H), 8.39-8.42 (m, 1H), 7.84-8.05 (m, 2H), 7.70-7.76 (m, 1H), 7.56-7.68 (m, 4H), 6.99 (d, J=3.8 Hz, 1H), 6.92 (d, J=3.8 Hz, 1H), 3.91-3.92 (bs, 2H); MS (ESI+) M/Z 430 (M+H)+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08629143B2 |
| 出典データセット | uspto-grants-2014_01 |
| ORD ID | ord-35fb7061da3e47c6b43a99cb207d06ed |
| 出典メモ | uspto-grants-2014_01 |