Tetrahydrofuran → 2-Amino-6-bromophenol

HRID 469824

反応式

HRID 469824 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[OH:11].C1COCC1>CO.[Ni]>[NH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([Br:1])[C:3]=1[OH:11]

参加物

5

反応物 2

HCID 8028TetrahydrofuranHCID 135454532-Bromo-6-nitrophenol

生成物 1

HCID 155315062-Amino-6-bromophenol

試薬・触媒・溶媒 2

HCID 935Nickel触媒HCID 887Methanol溶媒

実験手順

A solution of 5.3 g (22.7 mmol) 2-bromo-6-nitro-phenol in 100 ml MeOH:THF=1:1 is hydrogenated in the presence of 0.2 g Ra—Ni (in EtOH, Degussa B113W). The reaction mixture is filtered (2 glass fiber filters used) and the filtrate is concentrated in vacuo to afford the crude title compound.

後処理

  1. filtrationThe reaction mixture is filtered (2 glass fiber filters used)
  2. concentrationthe filtrate is concentrated in vacuo

出典と根拠

ORDレコード
ord-26bd5e9dcb284bcea424992ae7e1b2c8
出典データセット
uspto-grants-2014_01
特許番号
US08629168B2

関連ノート

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