Methanone, (2-chlorophenyl)phenyl- → 2-Chlorobenzhydrol, (+-)-

HRID 47003

反応式

HRID 47003 の反応式
[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4]([C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:5].[BH4-].[Na+]>C(O)(C)C>[Cl:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[CH:4]([OH:5])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

参加物

4

反応物 2

HCID 78838Methanone, (2-chlorophenyl)phenyl-HCID 4311764Sodium borohydride

生成物 1

HCID 2358192-Chlorobenzhydrol, (+-)-収率 76%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

A mixture containing 15.0 g (0.0692 mole) of 2-chlorobenzophenone, 4.1 g (0.1094 mole) of sodium borohydride, and 200 ml of anhydrous isopropanol is heated to reflux and maintained at reflux until the reaction is complete (2.0 hours), as indicated by vpc techniques. The solvent is removed in vacuo, whereupon the residue is diluted with ether, washed with a dilute hydrochloric acid solution and with water until neutral, dried (magnesium sulfate), and concentrated in vacuo. Recrystallization of the resulting residue from petroleum ether affords 11.5 g (0.0526 mole) of 2-chlorobenzhydrol, m.p. 61°-63°.

後処理

  1. temperatureis heated
  2. temperatureto reflux
  3. temperaturemaintained
  4. temperatureat reflux until the reaction
  5. custom(2.0 hours)
  6. customThe solvent is removed in vacuo, whereupon the residue
  7. additionis diluted with ether
  8. washwashed with a dilute hydrochloric acid solution and with water until neutral,
  9. dry with materialdried (magnesium sulfate)
  10. concentrationconcentrated in vacuo
  11. customRecrystallization of the resulting residue from petroleum ether

出典と根拠

ORDレコード
ord-c2744ee57a024e7487d75f296a69f439
出典データセット
uspto-grants-1979_11
特許番号
US04175945

関連ノート

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