2-Fluoroaniline → 4-Bromo-2-fluoroaniline
反応式
[Br:1]N1C(=O)CCC1=O.[F:9][C:10]1[CH:16]=[CH:15][CH:14]=[CH:13][C:11]=1[NH2:12]>C(Cl)Cl>[Br:1][C:15]1[CH:14]=[CH:13][C:11]([NH2:12])=[C:10]([F:9])[CH:16]=1参加物
4
実験手順
160 Parts of solid N-bromosuccinimide were added in portions over a 2 hour period to a solution of 100 parts of 2-fluoroaniline in 400 parts of methylene chloride cooled to 0°. After stirring for 20 minutes, the dark red mixture was washed four times; 200 parts of cold water were used for each washing. The red organic phase was dried with anhydrous sodium sulfate and evaporated at 300 mm.Hg to yield 164 parts of brown, oily 4-bromo-2-fluoroaniline, nD25 : 1.5885.
後処理
- temperaturecooled to 0°
- washthe dark red mixture was washed four times
- dry with materialThe red organic phase was dried with anhydrous sodium sulfate
- customevaporated at 300 mm.Hg
出典と根拠
- ORDレコード
- ord-637cb1ab1673407aa14706e6cc2e10fc
- 出典データセット
- uspto-grants-1979_11
- 特許番号
- US04175948
反応ノート
読み込み中…