2-Fluoroaniline → 4-Bromo-2-fluoroaniline

160 Parts of solid N-bromosuccinimide were added in portions over a 2 hour period to a solution of 100 parts of 2-fluoroaniline in 400 parts of methylene chloride cooled to 0°. After stirring for 20 minutes, the dark red mixture was washed four times; 200 parts of cold water were used for each washing. The red organic phase was dried with anhydrous sodium sulfate and evaporated at 300 mm.Hg to yield 164 parts of brown, oily 4-bromo-2-fluoroaniline, nD25 : 1.5885.

1. temperaturecooled to 0°
2. washthe dark red mixture was washed four times
3. dry with materialThe red organic phase was dried with anhydrous sodium sulfate
4. customevaporated at 300 mm.Hg

ORDレコード

ord-637cb1ab1673407aa14706e6cc2e10fc

出典データセット

uspto-grants-1979_11

DOI

10.6084/m9.figshare.5104873.v1

特許番号

US04175948